Dangers of statins -Lipitor, Zocor and others

By Sally Fallon and Mary Enig Phd.

Hypercholesterolemia is the health issue of the 21st century. It is actually an invented disease, a “problem” that emerged when health professionals learned how to measure cholesterol levels in the blood. High cholesterol exhibits no outward signs–unlike other conditions of the blood, such as diabetes or anemia, diseases that manifest telltale symptoms like thirst or weakness–hypercholesterolemia requires the services of a physician to detect its presence. Many people who feel perfectly healthy suffer from high cholesterol–in fact, feeling good is actually a symptom of high cholesterol!

Doctors who treat this new disease must first convince their patients that they are sick and need to take one or more expensive drugs for the rest of their lives, drugs that require regular checkups and blood tests. But such doctors do not work in a vacuum–their efforts to convert healthy people into patients are bolstered by the full weight of the US government, the media and the medical establishment, agencies that have worked in concert to disseminate the cholesterol dogma and convince the population that high cholesterol is the forerunner of heart disease and possibly other diseases as well.

Who suffers from hypercholesterolemia? Peruse the medical literature of 25 or 30 years ago and you’ll get the following answer: any middle-aged man whose cholesterol is over 240 with other risk factors, such as smoking or overweight. After the Cholesterol Consensus Conference in 1984, the parameters changed; anyone (male or female) with cholesterol over 200 could receive the dreaded diagnosis and a prescription for pills. Recently that number has been moved down to 180. If you have had a heart attack, you get to take cholesterol-lowering medicines even if your cholesterol is already very low–after all, you have committed the sin of having a heart attack so your cholesterol must therefore be too high. The penance is a lifetime of cholesterol-lowering medications along with a boring lowfat diet. But why wait until you have a heart attack? Since we all labor under the stigma of original sin, we are all candidates for treatment. Current edicts stipulate cholesterol testing and treatment for young adults and even children.

The drugs that doctors use to treat the new disease are called statins–sold under a variety of names including Lipitor (atorvastatin), Zocor (simvastatin), Mevacor (lovastatin) and Pravachol (pravastatin).

How Statins Work

The diagram below illustrates the pathways involved in cholesterol production. The process begins with acetyl-CoA, a two-carbon molecule sometimes referred to as the “building block of life.” Three acetyl-CoA molecules combine to form six-carbon hydroxymethyl glutaric acid (HMG). The step from HMG to mevalonate requires an enzyme, HMG-CoA reductase. Statin drugs work by inhibiting this enzyme–hence the formal name of HMG-CoA reductase inhibitors. Herein lies the potential for numerous side effects, because statin drugs inhibit not just the production of cholesterol, but a whole family of intermediary substances, many if not all of which have important biochemical functions in their own right.

Consider the findings of pediatricians at the University of California, San Diego who published a description of a child with an hereditary defect of mevalonic kinase, the enzyme that facilitates the next step beyond HMG-CoA reductase.1 The child was mentally retarded, microcephalic (very small head), small for his age, profoundly anemic, acidotic and febrile. He also had cataracts. Predictably, his cholesterol was consistently low–70-79 mg/dl. He died at the age of 24 months. The child represents an extreme example of cholesterol inhibition, but his case illuminates the possible consequences of taking statins in strong doses or for a lengthy period of time–depression of mental acuity, anemia, acidosis, frequent fevers and cataracts.

Cholesterol is one of three end products in the mevalonate chain. The two others are ubiquinone and dilochol. Ubiquinone or Co-Enzyme Q10 is a critical cellular nutrient biosynthesized in the mitochondria. It plays a role in ATP production in the cells and functions as an electron carrier to cytochrome oxidase, our main respiratory enzyme. The heart requires high levels of Co-Q10. A form of Co-Q10 called ubiquinone is found in all cell membranes where it plays a role in maintaining membrane integrity so critical to nerve conduction and muscle integrity. Co-Q10 is also vital to the formation of elastin and collagen. Side effects of Co-Q10 deficiency include muscle wasting leading to weakness and severe back pain, heart failure (the heart is a muscle!), neuropathy and inflammation of the tendons and ligaments, often leading to rupture.

Dolichols also play a role of immense importance. In the cells they direct various proteins manufactured in response to DNA directives to their proper targets, ensuring that the cells respond correctly to genetically programmed instruction. Thus statin drugs can lead to unpredictable chaos on the cellular level, much like a computer virus that wipes out certain pathways or files.

Squalene, the immediate precursor to cholesterol, has anti-cancer effects, according to research.

The fact that some studies have shown that statins can prevent heart disease, at least in the short term, is most likely explained not by the inhibition of cholesterol production but because they block the creation of mevalonate. Reduced amounts of mevalonate seem to make smooth muscle cells less active, and platelets less able to produce thromboxane. Atherosclerosis begins with the growth of smooth muscle cells in side artery walls and thromboxane is necessary for blood clotting.

When I was a pharmaceutical sales rep I sold a statin. The cholesterol guidelines were established by physicians.  Many of the experts who participated in writing the guidelines for cholesterol disclosed various financial relationships with the pharmaceutical firms who manufacture statins.

When  a patient is on a statin like Lipitor or Zocor that then requires more doctor visits in order to do blood tests to check to make sure the liver is functioning properly and that there is no muscle damage occuring.

The archives of internal medicine in 1993 showed that elevated total cholesterol levels correlate with an increased risk of death only through the age of 40 and not once after the age of 50. Most people that take statins are after the age of 50. Each statin pill costs roughly three dollars. Millions of people are taking these drugs that don’t need to be. The terrible irony in all of this is that you actually NEED cholesterol. It helps the brain to function and it helps the nerves to funtion properly. With the Millions of people on this high priced medication it is costing us taxpayers billions of dollars of wasteful spending.   

2 Responses to “Dangers of statins -Lipitor, Zocor and others”

  1. garytby Says:

    I wholeheartedly agree with this post. Cholesterol is needed
    for healthy body/brain functions. The ‘high cholesterol’ scam
    has been a huge money maker for all those involved in the
    medical community and especially for the makers of statins.

    From all my observations on this subject, both from what
    I’ve read and what I’ve witnessed first hand by the people
    I personally know that have taken statins, I have come to the conclusion that these drugs do far more harm than good to the people that take them.

    I have witnessed older friends that had to give up their daily
    walks due to achy joints and weakened muscles after taking
    statins for a few months. I have seen these drugs bring on
    arthritis in people soon after starting on statins, yet when I
    asked them why they didn’t stop taking them immediately,
    they would all tell me that they had to take them under their
    Dr’s orders or they would have a heart attack or stroke.

    Dr’s have found Fear to be a very helpful tool in convincing
    most of their patients to take many drugs that they don’t
    necessarily need, but have been told they won’t live long
    without them. Most people still consider their Dr. to be a
    type of medicine God that has all the answers, and to not follow their Dr’s orders would certainly lead to their demise.

    I think more people are harmed by following their Dr’s advice
    than by not following it. People need to wake up and take a
    more pro-active role in their own health care. The computer
    can be your best friend if you are looking for answers to your health questions. Never let your Dr. tell you that you
    need to stay off the net and only follow his or her advice
    alone. A qualified Dr. would never tell you that unless they had something to hide….. like their own lack of knowledge.

    Many Dr’s have their patients on 10 - 12 different drugs all
    at the same time with little to no understanding of what the
    interactions of all these drugs may be.

    Times have changed people. Your health is not the main
    priority to them anymore….money is now. Maybe it always
    was, but now more than ever.

  2. Rod Souza Says:

    Is there an alternative to this insane Levaquin that won’t destroy your life?
    Thank you.

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